• DOI:10.1038/nn1685
Corpus ID: 11812089

A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans

@article{Sandoval2006AGI,
  title={A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans},
  author={G. M. Sandoval and J. Duerr and J. Hodgkin and J. Rand and G. Ruvkun},
  journal={Nature Neuroscience},
  year={2006},
  volume={9},
  pages={599-601}
}

• G. M. Sandoval, J. Duerr, +2 authors G. Ruvkun
• Published 2006
• Biology, Medicine
• Nature Neuroscience

Acetylcholine, a major excitatory neurotransmitter in Caenorhabditis elegans, is transported into synaptic vesicles by the vesicular acetylcholine transporter encoded by unc-17. The abnormal behavior of unc-17(e245) mutants, which have a glycine-to-arginine substitution in a transmembrane domain, is markedly improved by a mutant synaptobrevin with an isoleucine-to-aspartate substitution in its transmembrane domain. These results suggest an association of vesicular soluble N-ethylmaleimide… Expand

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