A genetic fusion GDNF-C fragment of tetanus toxin prolongs survival in a symptomatic mouse ALS model.

@article{Ciriza2008AGF,
  title={A genetic fusion GDNF-C fragment of tetanus toxin prolongs survival in a symptomatic mouse ALS model.},
  author={Jes{\'u}s Ciriza and Mar{\'i}a Moreno-Igoa and Ana Cristina Calvo and Genoveva Yague and J. C. Castro Palacio and F J Miana-Mena and M Mu{\~n}oz and Pilar Zaragoza and Philippe Br{\^u}let and Rosario Osta},
  journal={Restorative neurology and neuroscience},
  year={2008},
  volume={26 6},
  pages={459-65}
}
PURPOSE Amyotrophic Lateral Sclerosis (ALS) is a paralyzing disorder that kills individuals within three to five years of onset without any possibility for effective treatment. One proposed therapy has been the use of neurotrophic factors to inhibit the apoptosis of motorneurones. At the present, one way to deliver neurotrophic factors after intramuscular injection to the motor neurones is through the use of adenoviral vectors. An alternative strategy is the use of the atoxic C fragment of… CONTINUE READING
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