A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

  title={A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome},
  author={Frances K. Wiseman and T. A. Al-Janabi and John Hardy and Annette Karmiloff-Smith and D. Nizetic and Victor L. J. Tybulewicz and Elizabeth M. C. Fisher and Andre Strydom},
  journal={Nature Reviews Neuroscience},
Down syndrome, which arises in individuals carrying an extra copy of chromosome 21, is associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that this risk is conferred by the presence of three copies of the gene encoding amyloid precursor protein (APP) — an Alzheimer disease risk factor — although the possession of extra copies of other chromosome 21 genes may also play a part. Further study of the mechanisms underlying the development of Alzheimer disease in… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 38 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 62 extracted citations


Publications referenced by this paper.
Showing 1-10 of 216 references

AgeneticcauseofAlzheimerdisease : mechanisticinsightsfromDownsyndrome

  • E. Fisher
  • NatureReviewsNeuroscience
  • 2015

Estimates of the live births, natural losses, and elective terminations with Down syndrome in the United States

  • G de Graaf, F Buckley, BG. Skotko
  • Am. J. Med. Genet. A
  • 2015

Similar Papers

Loading similar papers…