A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

@article{Wiseman2015AGC,
  title={A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome},
  author={Frances K. Wiseman and T. A. Al-Janabi and John Hardy and Annette Karmiloff-Smith and D. Nizetic and Victor L. J. Tybulewicz and Elizabeth M. C. Fisher and Andre Strydom},
  journal={Nature Reviews Neuroscience},
  year={2015},
  volume={16},
  pages={564-574}
}
Down syndrome, which arises in individuals carrying an extra copy of chromosome 21, is associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that this risk is conferred by the presence of three copies of the gene encoding amyloid precursor protein (APP) — an Alzheimer disease risk factor — although the possession of extra copies of other chromosome 21 genes may also play a part. Further study of the mechanisms underlying the development of Alzheimer disease in… CONTINUE READING
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AgeneticcauseofAlzheimerdisease : mechanisticinsightsfromDownsyndrome

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