A genetic basis for familial aggregation in multiple sclerosis

  title={A genetic basis for familial aggregation in multiple sclerosis},
  author={George Cornell Ebers and Adele Dessa Sadovnick and Neil J. Risch},
GENETIC-environmental interactions probably underlie spontaneous human autoimmune disorders, a category of complex traits thought to include multiple sclerosis (MS)1. The geographical distribution and familial aggregation of this disease have often been ascribed to the role of infectious agents2, but there is no consensus. Increased family risks range from 300-fold3,4 for monozygotic twins to 20–40-fold5 for biological first-degree relatives over the general population prevalence of 0.1% (ref… CONTINUE READING

From This Paper

Topics from this paper.
216 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 216 extracted citations

Similar Papers

Loading similar papers…