A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance

@article{Mah2003AGB,
  title={A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance},
  author={Thien-Fah Mah and Betsey Pitts and Brett J. Pellock and Graham C. Walker and Philip S Stewart and George A. O’Toole},
  journal={Nature},
  year={2003},
  volume={426},
  pages={306-310}
}
Biofilms are surface-attached microbial communities with characteristic architecture and phenotypic and biochemical properties distinct from their free-swimming, planktonic counterparts. One of the best-known of these biofilm-specific properties is the development of antibiotic resistance that can be up to 1,000-fold greater than planktonic cells. We report a genetic determinant of this high-level resistance in the Gram-negative opportunistic pathogen, Pseudomonas aeruginosa. We have identified… 
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