A genetic analysis of the sex-determining gene, tra-1, in the nematode Caenorhabditis elegans.

@article{Hodgkin1987AGA,
  title={A genetic analysis of the sex-determining gene, tra-1, in the nematode Caenorhabditis elegans.},
  author={Jonathan Hodgkin},
  journal={Genes & development},
  year={1987},
  volume={1 7},
  pages={731-45}
}
The normal sexes of Caenorhabditis elegans are the self-fertilizing hermaphrodite (XX) and the male (XO). The autosomal gene tra-1 is a major switch gene controlling sexual phenotype. Mutant phenotypes of 43 loss-of-function (lf) tra-1 alleles and 22 gain-of-function (gf) tra-1 alleles are described and discussed. The tra-1(lf) alleles are recessive and, in general, masculinizing. The most severe mutations (such as seven out of eight identified amber alleles) can transform XX animals into… CONTINUE READING
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