A generalized framework for network component analysis

  title={A generalized framework for network component analysis},
  author={Riccardo Boscolo and Chiara Sabatti and James C. Liao and Vwani P. Roychowdhury},
  journal={IEEE/ACM Transactions on Computational Biology and Bioinformatics},
The authors recently introduced a framework, named Network Component Analysis (NCA), for the reconstruction of the dynamics of transcriptional regulators' activities from gene expression assays. The original formulation had certain shortcomings that limited NCA's application to a wide class of network dynamics reconstruction problems, either because of limitations in the sample size or because of the stringent requirements imposed by the set of identifiability conditions. In addition, the… CONTINUE READING