A generalized Luria-Delbrück model.

  title={A generalized Luria-Delbr{\"u}ck model.},
  author={Anup Dewanji and E. Georg Luebeck and Suresh H. Moolgavkar},
  journal={Mathematical biosciences},
  volume={197 2},
We develop extensions of the Luria-Delbrück model that explicitly consider non-exponential growth of normal cells and a birth-death process with mean exponential or Gompertz growth of mutants. Death of mutant cells can be important in clones arising during cancer progression. The use of a birth-death process for growth of mutant cells, as opposed to a pure birth process as in previous work on the Luria-Delbrück model, leads to a large increase in the extra Poisson variation in the size of the… CONTINUE READING

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