A general synthetic method for the formation of substituted 5-aminotetrazoles from thioureas: a strategy for diversity amplification.

@article{Batey2000AGS,
  title={A general synthetic method for the formation of substituted 5-aminotetrazoles from thioureas: a strategy for diversity amplification.},
  author={Robert T Batey and David A Powell},
  journal={Organic letters},
  year={2000},
  volume={2 20},
  pages={3237-40}
}
A general method for the synthesis of 5-aminotetrazoles is outlined using the mercury(II)-promoted attack of azide anion on a thiourea. The reaction proceeds through a guanyl azide intermediate, which undergoes electrocyclization to the tetrazole. The method is high yielding and provides access to mono-, di-, and trisubstituted 5-aminotetrazoles, targets of… CONTINUE READING