A general survey of thymocyte differentiation by transcriptional analysis of knockout mouse models.

@article{Puthier2004AGS,
  title={A general survey of thymocyte differentiation by transcriptional analysis of knockout mouse models.},
  author={Denis Puthier and Florence Joly and Magali Irla and Murielle Saade and Genevi{\`e}ve Victorero and B{\'e}atrice Loriod and Catherine Nguyen},
  journal={Journal of immunology},
  year={2004},
  volume={173 10},
  pages={6109-18}
}
The thymus is the primary site of T cell lymphopoiesis. To undergo proper differentiation, developing T cells follow a well-ordered genetic program that strictly depends on the heterogeneous and highly specialized thymic microenvironment. In this study, we used microarray technology to extensively describe transcriptional events regulating alphabeta T cell fate. To get an integrated view of these processes, both whole thymi from genetically engineered mice together with purified thymocytes were… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
18 Citations
64 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 64 references

Similar Papers

Loading similar papers…