A general phosphoric acid-catalyzed desymmetrization of meso-aziridines with silylated selenium nucleophiles.

Abstract

The first example of meso-aziridine desymmetrization with selenium nucleophiles is reported. The reaction, promoted by VAPOL-hydrogen phosphate using (phenylseleno)trimethylsilane as the nucleophile, proves to be very general and highly enantioselective (84-99% ee).

DOI: 10.1039/c1ob05837a

Cite this paper

@article{Senatore2011AGP, title={A general phosphoric acid-catalyzed desymmetrization of meso-aziridines with silylated selenium nucleophiles.}, author={Matilde Senatore and Alessandra Lattanzi and Stefano Santoro and Claudio Santi and Giorgio Della Sala}, journal={Organic & biomolecular chemistry}, year={2011}, volume={9 18}, pages={6205-7} }