A general method for quantifying sequence effects on nucleobase oxidation in DNA.

Abstract

Oxidative damage to DNA has long been associated with aging and disease, with guanine serving as the primary target for oxidation owing to its low ionization potential. Emerging evidence points to a critical role for sequence context as a determinant of the guanine ionization potential and the associated chemical reactivity of the guanine, as well as the… (More)
DOI: 10.1007/978-1-60327-029-8_19

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