A general method for controlling the genome-wide type I error rate in linkage and association mapping experiments in plants

@article{Mueller2011AGM,
  title={A general method for controlling the genome-wide type I error rate in linkage and association mapping experiments in plants},
  author={Beatrice U. Mueller and Benjamin Stich and H P Piepho},
  journal={Heredity},
  year={2011},
  volume={106},
  pages={825-831}
}
Control of the genome-wide type I error rate (GWER) is an important issue in association mapping and linkage mapping experiments. For the latter, different approaches, such as permutation procedures or Bonferroni correction, were proposed. The permutation test, however, cannot account for population structure present in most association mapping populations. This can lead to false positive associations. The Bonferroni correction is applicable, but usually on the conservative side, because… CONTINUE READING