A general method applicable to the search for similarities in the amino acid sequence of two proteins.

@article{Needleman1970AGM,
  title={A general method applicable to the search for similarities in the amino acid sequence of two proteins.},
  author={S. B. Needleman and C. D. Wunsch},
  journal={Journal of molecular biology},
  year={1970},
  volume={48 3},
  pages={
          443-53
        }
}
A computer adaptable method for finding similarities in the amino acid sequences of two proteins has been developed. From these findings it is possible to determine whether significant homology exists between the proteins. This information is used to trace their possible evolutionary development. The maximum match is a number dependent upon the similarity of the sequences. One of its definitions is the largest number of amino acids of one protein that can be matched with those of a second… Expand
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This work was supported in part by grants to one of us (S.B.N.) from the U.S. Public Health Service (1 501 FR 05370 02) and from Merck Sharp & Dohme
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