A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress.

@article{Kang2009AGM,
  title={A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress.},
  author={Jinsuk Kang and Matthew Gemberling and M. Nakamura and Frank G. Whitby and Hiroshi Handa and William G. Fairbrother and Dean Tantin},
  journal={Genes & development},
  year={2009},
  volume={23 2},
  pages={208-22}
}
Oct1 and Oct4 are homologous transcription factors with similar DNA-binding specificities. Here we show that Oct1 is dynamically phosphorylated in vivo following exposure of cells to oxidative and genotoxic stress. We further show that stress regulates the selectivity of both proteins for specific DNA sequences. Mutation of conserved phosphorylation target DNA-binding domain residues in Oct1, and Oct4 confirms their role in regulating binding selectivity. Using chromatin immunoprecipitation, we… CONTINUE READING