A general likelihood approach to trait-based multipoint linkage analysis in large groups of half-sibs and super sisters.

Abstract

The idea of trait-based linkage analysis in half-sibs is extended by comparing the frequency of parental marker haplotypes in animals with different phenotypes. This article first presents the likelihood of observing different classes of paternal haplotypes in a half-sib family, where only family members of a certain phenotype (e.g., affected) are genotyped… (More)

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