A general catalytic reaction sequence to access alkaloid-inspired indole polycycles.

Abstract

A catalytic two-step reaction sequence was developed to access a range of complex heterocyclic frameworks based on biorelevant indole/oxindole scaffolds. The reaction sequence includes catalytic Pictet-Spengler cyclization followed by Au(I) catalyzed intramolecular hydroamination of acetylenes. A related cascade polycyclization of a designed β-carboline… (More)
DOI: 10.1039/c5cc01555c

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