A general best-fit method for concentration-response curves and the estimation of low-effect concentrations.

@article{Scholze2001AGB,
  title={A general best-fit method for concentration-response curves and the estimation of low-effect concentrations.},
  author={Martin Scholze and Wolfgang Boedeker and M. S. John B. Faust and Thomas Backhaus and Rolf Altenburger and L. Horst Grimme},
  journal={Environmental toxicology and chemistry},
  year={2001},
  volume={20 2},
  pages={448-57}
}
Risk assessments of toxic chemicals currently rely heavily on the use of no-observed-effect concentrations (NOECs). Due to several crucial flaws in this concept, however, discussion of replacing NOECs with statistically estimated low-effect concentrations continues. This paper describes a general best-fit method for the estimation of effects and effect concentrations by the use of a pool of 10 different sigmoidal regression functions for continuous toxicity data. Due to heterogeneous… CONTINUE READING

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