A general approach to cyathin diterpenes. Total synthesis of allocyathin B(3).

@article{Ward2000AGA,
  title={A general approach to cyathin diterpenes. Total synthesis of allocyathin B(3).},
  author={Dale Ward and Yuanzhu Gai and Qin Qiao},
  journal={Organic letters},
  year={2000},
  volume={2 14},
  pages={
          2125-7
        }
}
[reaction: see text] The synthesis of allocyathin B(3) from an advanced intermediate possessing the ring system and relative stereochemistry but lacking the isopropyl and hydroxymethyl groups is reported. The isopropyl group was introduced by radical cyclization of a methyl propargyl acetal of an alpha-bromo ketone, and the hydroxymethyl group was generated by Pd-catalyzed carbonylation of a vinyl triflate. The route provides functionalized intermediates that could allow access to more complex… CONTINUE READING
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