A general amphipathic α-helical motif for sensing membrane curvature

@article{Drin2007AGA,
  title={A general amphipathic $\alpha$-helical motif for sensing membrane curvature},
  author={Guillaume Drin and J F Casella and Romain Gautier and Thomas Boehmer and Thomas U. Schwartz and Bruno Antonny},
  journal={Nature Structural \&Molecular Biology},
  year={2007},
  volume={14},
  pages={138-146}
}
The Golgi-associated protein ArfGAP1 has an unusual membrane-adsorbing amphipathic α-helix: its polar face is weakly charged, containing mainly serine and threonine residues. We show that this feature explains the specificity of ArfGAP1 for curved versus flat lipid membranes. We built an algorithm to identify other potential amphipathic α-helices rich in serine and threonine residues in protein databases. Among the identified sequences, we show that three act as membrane curvature sensors. In… 

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