A gene-wide investigation on polymorphisms in the ABCG2/BRCP transporter and susceptibility to colorectal cancer.

@article{Campa2008AGI,
  title={A gene-wide investigation on polymorphisms in the ABCG2/BRCP transporter and susceptibility to colorectal cancer.},
  author={Daniele Campa and Barbara Pardini and Alessio Naccarati and Ludmila Vodi{\vc}kov{\'a} and Jan Novotn{\'y} and Asta Foersti and Kari Hemminki and Roberto Barale and Pavel Erik Vodicka and Frederico Canzian},
  journal={Mutation research},
  year={2008},
  volume={645 1-2},
  pages={56-60}
}
ATP-binding cassette (ABC) transporters actively export a wide variety of molecules from cells, contributing to reduce the local cellular burden of toxic compounds. ABCG2/BCRP is abundantly expressed in epithelial cells of the intestine and colon. The expression and activity of this transporter in the gut differ between individuals, due at least in part to genetic polymorphisms, which may thus affect the risk of colorectal cancer (CRC). We selected 15 tagging SNPs, covering all the known… CONTINUE READING
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