A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population.

@article{Verrijken2013AGV,
  title={A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population.},
  author={An Verrijken and Sigri Beckers and Sven M Francque and H. Hilden and Sandrine Caron and Doreen Zegers and Martin Ruppert and Guy Hubens and Eric van Marck and Peter P Michielsen and Bart Staels and Marja-Riitta Taskinen and Wim van Hul and Luc Van Gaal},
  journal={Obesity},
  year={2013},
  volume={21 10},
  pages={2138-45}
}
OBJECTIVE Mechanisms explaining the relationship in non-alcoholic fatty liver disease (NAFLD), obesity, and insulin resistance are poorly understood. A genetic basis has been suggested. We studied the association between the genes patatin-like phospholipase domain-containing protein 3 (PNPLA3) and apolipoprotein C3 (APOC3) and metabolic and histological parameters of NAFLD in obese patients. DESIGN AND METHODS Overweight and obese patients underwent a metabolic and liver assessment. If NAFLD… CONTINUE READING
21 Citations
43 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Similar Papers

Loading similar papers…