A gene network inference method from continuous-value gene expression data of wild-type and mutants.

@article{Kyoda2000AGN,
  title={A gene network inference method from continuous-value gene expression data of wild-type and mutants.},
  author={Koji Kyoda and Mineo Morohashi and Shuichi Onami and Hiroaki Kitano},
  journal={Genome informatics. Workshop on Genome Informatics},
  year={2000},
  volume={11},
  pages={196-204}
}
In this paper we introduce a new inference method of a gene regulatory network from steady-state gene expression data. Our method determines a regulatory structure consistent with an observed set of steady-state expression profiles, each generated from wild-type and single deletion mutant of the target network. Our method derives the regulatory relationships in the network using a graph theoretic approach. The advantage of our method is to be able to deal with continuous values of steady-state… CONTINUE READING

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