Corpus ID: 16426256

A gene network approach to modeling early neurogenesis in Drosophila.

@article{Marnellos1998AGN,
  title={A gene network approach to modeling early neurogenesis in Drosophila.},
  author={G. Marnellos and E. Mjolsness},
  journal={Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing},
  year={1998},
  pages={
          30-41
        }
}
  • G. Marnellos, E. Mjolsness
  • Published 1998
  • Biology, Medicine
  • Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
We have produced a model of genetic regulation to simulate how neuroblasts and sensory organ precursor (SOP) cells differentiate from proneural clusters of equivalent cells. Parameters of the model (mainly gene interaction strengths) are optimized in order to fit schematic patterns of expression, drawn from the literature, of genes that are involved in this process of cell fate specification. The model provides suggestions about the role of lateral signalling in neurogenesis and yields specific… Expand
Probing the dynamics of cell di erentiation in a model of DrosophilaneurogenesisGeorge
We have formulated a computational model of Drosophila early neurogenesis, the process by which neu-roblasts and sensory organ precursor (SOP) cells differentiate from within proneural clusters ofExpand
A gene regulatory network for cell differentiation in caenorhabditis elegans
TLDR
A simple recurrent network is used to model the process of gene regulation and evolved systems that were able to generate the first four cell divisions of the C. elegans cell lineage tree with a high degree of accuracy. Expand
The gene network determining development of Drosophila melanogaster mechanoreceptors
TLDR
This work systematize the experimental data on the main genes and their products involved in the control of proneural clusters in the ectoderm of imaginal discs and determination of the sensory organ precursor (SOP) cell within the proneural cluster clusters. Expand
Trainable Gene Regulation Networks with Applications to Drosophila Pattern Formation
This chapter will very briefly introduce and review some computational experiments in using trainable gene regulation network models to simulate and understand selected episodes in the development ofExpand
Gene regulation networks with signaling and cell division in development simulations
The shoot apical meristem (SAM) of Arabidopsis thaliana is an example of a developmental system which can be modeled at genetic and mechanical levels provided that suitable mathematical andExpand
Model investigation of central regulatory contour of gene net of D. melanogaster macrochaete morphogenesis
TLDR
A mathematical model of CRC functioning as a regulator of proneural AS-C protein content in SOP cell determining successful passing of the main phase of morphogenesis of D. melanogaster mechanoreceptor is discussed. Expand
Modeling Plant Development with Gene Regulation Networks Including Signaling and Cell Division
TLDR
A simplified dynamical 2-dimensional model of a growing plant where cells in the shoot grow and proliferate, while the number of stem cells at the apex stays constant due to differentiation into tissue cells. Expand
Neutrality and Robustness in Evo-Devo: Emergence of Lateral Inhibition
TLDR
This analysis shows that evolution leads to a class of robust genetic networks with an expression pattern characteristic of lateral inhibition, which is a repertoire of distinct implementations of this key developmental process, the diversity of which provides valuable clues about its underlying causal principles. Expand
Gene network controlling the morphogenesis of D. melanogaster macrochaetes: An expanded model of the central regulatory circuit
TLDR
A mathematical model describing the CRC functioning in the SOP cell as a regulator of the content of ASC proneural proteins is proposed. Expand
Morphogenesis in plants: modeling the shoot apical meristem, and possible applications
TLDR
This work exhibits a very preliminary two-dimensional model including gene regulation and intercellular signaling, but omitting cell division and dynamical geometry, of overall morphogenesis in flowering plants such as Arabidopsis thaliana. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 13 REFERENCES
Developmental Biology
Current Topics in Developmental BiologyVol. 2. Edited by A. A. Moscona and Alberto Monroy. Pp. xiii + 298. (New York: Academic Press, Inc.; London: Academic Press, Inc. (London), Ltd., 1967.) 112s.
Mechanisms of Development
Analysis of DevelopmentEdited by Prof. Benjamin H. Willier, Prof. Paul A. Weiss and Prof. Viktor Hamburger. Pp. xii + 735. (Philadelphia and London: W. B. Saunders Company, 1955.) 105s.
Current opinion in neurobiology
Gene Network Models Applied to Questions in Development and Evolution
  • Gene Network Models Applied to Questions in Development and Evolution
  • 1997
Abstracts of the 37th Annual Drosophila Research Conference
  • Abstracts of the 37th Annual Drosophila Research Conference
  • 1996
Development
  • Current Opinion in Neurobiology
  • 1996
i n A bstracts of the 37th Annual Drosophila Research Conference
  • i n A bstracts of the 37th Annual Drosophila Research Conference
  • 1996
i n Abstracts of the 37th Annual Drosophila Research Conference
  • i n Abstracts of the 37th Annual Drosophila Research Conference
  • 1996
Gene Network Models Applied to Questions in Develop- ment and Evolution, Ph.D. thesis, Yale University
  • Trends in Genetics
  • 1992
Gene Network Models Applied to Questions in Development and Evolution, Ph.D
  • Trends in Genetics
  • 1992
...
1
2
...