A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme.

@article{Kok1993AGI,
  title={A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme.},
  author={Klaas Kok and Robert Hofstra and Andreas Pilz and Anke van den Berg and P. Terpstra and C. H. Buys and Ben Carritt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 13},
  pages={6071-5}
}
The chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We recently cloned a gene from this region that has greatly reduced expression in almost all lung tumor cell lines examined, in spite of being widely expressed in a variety of other tumor and nontumor cell types. We report here the sequence of this gene and show that it has significant homology to the genes encoding the ubiquitin-activating enzymes of three species, including humans. This suggests it is a… CONTINUE READING

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