A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome

@article{Brown1991AGF,
  title={A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome},
  author={C J Brown and Andrea Ballabio and James L. Rupert and Ronald G. Lafreni{\'e}re and Markus Grompe and Rossana Tonlorenzi and Huntington F. Willard},
  journal={Nature},
  year={1991},
  volume={349},
  pages={38-44}
}
X-chromosome inactivation results in the cis-limited dosage compensation of genes on one of the pair of X chromosomes in mammalian females. Although most X-linked genes are believed to be subject to inactivation, several are known to be expressed from both active and inactive X chromosomes. Here we describe an X-linked gene with a novel expression pattern—transcripts are detected only from the inactive X chromosome (Xi) and not from the active X chromosome (Xa). This gene, called XIST (for Xi… CONTINUE READING
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