A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif

@article{Sinclair1990AGF,
  title={A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif},
  author={A. Sinclair and P. Berta and M. S. Palmer and J. R. Hawkins and B. Griffiths and M. Smith and J. W. Foster and A. Frischauf and R. Lovell-Badge and P. Goodfellow},
  journal={Nature},
  year={1990},
  volume={346},
  pages={240-244}
}
  • A. Sinclair, P. Berta, +7 authors P. Goodfellow
  • Published 1990
  • Biology, Medicine
  • Nature
  • A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. This gene has been termed SRY (for sex… CONTINUE READING
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