A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
@article{Sinclair1990AGF, title={A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif}, author={A. Sinclair and P. Berta and M. S. Palmer and J. R. Hawkins and B. Griffiths and M. Smith and J. W. Foster and A. Frischauf and R. Lovell-Badge and P. Goodfellow}, journal={Nature}, year={1990}, volume={346}, pages={240-244} }
A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. This gene has been termed SRY (for sex… CONTINUE READING
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