A gene for neuronal plasticity in the mammalian brain: Zif268/Egr-1/NGFI-A/Krox-24/TIS8/ZENK?

@article{Knapska2004AGF,
  title={A gene for neuronal plasticity in the mammalian brain: Zif268/Egr-1/NGFI-A/Krox-24/TIS8/ZENK?},
  author={E. Knapska and L. Kaczmarek},
  journal={Progress in Neurobiology},
  year={2004},
  volume={74},
  pages={183-211}
}
Zif268 is a transcription regulatory protein, the product of an immediate early gene. Zif268 was originally described as inducible in cell cultures; however, it was later shown to be activated by a variety of stimuli, including ongoing synaptic activity in the adult brain. Recently, mice with experimentally mutated zif268 gene have been obtained and employed in neurobiological research. In this review we present a critical overview of Zif268 expression patterns in the naive brain and following… Expand
c-Fos and Zif268 in Learning and Memory—Studies on Expression and Function
TLDR
Since c-Fos and Zif268 are both TF, they bind with specific DNA sequences to regulate the activity of target genes and thus may be the key players in guiding the cell’s response to various stimuli. Expand
Zif268/Egr1 gain of function facilitates hippocampal synaptic plasticity and long-term spatial recognition memory
TLDR
It is found that Zif268 overexpression during the establishment of memory for objects did not change the ability to form a long-term memory of objects, but enhanced the capacity to formA long- term memory of the spatial location of objects. Expand
Egr-1-d2EGFP transgenic rats identify transient populations of neurons and glial cells during postnatal brain development.
TLDR
It is shown that Egr-1 is more widely expressed in the neonatal brain than was previously appreciated, and is not restricted to neurons; it is expressed in glial cells in the postnatal neocortex and hippocampus and in a novel population of cells associated with Cajal-Retzius-like neurons within the marginal zone of the postnat neocortex. Expand
Crosstalk Between Glucocorticoid Receptor and Early-growth Response Protein 1 Accounts for Repression of Brain-derived Neurotrophic Factor Transcript 4 Expression
TLDR
A mechanism by which GR downregulates Bdnf expression is deciphered, identifying a novel functional crosstalk between glucocorticoid pathways, immediate early growth response proteins and Bdnm, which may have significant implications in neurosciences as well as in therapeutics. Expand
The transcription factor Zif268/Egr1, brain plasticity, and memory.
TLDR
This work focuses on one such activity-dependent transcription factor, Zif268, known to be implicated in neuronal plasticity and memory formation, and summarizes current knowledge about its regulation and function in different types of brain plasticities and memory processes. Expand
Contribution of Egr1/zif268 to Activity-Dependent Arc/Arg3.1 Transcription in the Dentate Gyrus and Area CA1 of the Hippocampus
TLDR
Findings suggest that hippocampal neural ensembles are normally activated immediately following spatial exploration in Egr1 knockout mice, indicating normal hippocampal encoding of information and provide evidence that in condition of strong activation Egr 1 alone can control late-phases of activity-dependent Arc transcription in the dentate gyrus and area CA1 of the hippocampus. Expand
Transcriptional Signatures of Cellular Plasticity in Mice Lacking the α1 Subunit of GABAA Receptors
TLDR
The results suggest that the loss of α1-mediated fast inhibition produces diverse transcriptional responses that act to regulate neuronal excitability of individual neurons and stabilize neuronal networks, which may account for the lack of severe abnormalities in α1 null mutants. Expand
Regulation of expression of early growth response transcription factors in rat primary cortical neurons by extracellular ATP
TLDR
It is suggested that neuronal metabotropic purinergic receptor activation contributes to the induction of early growth response transcription factors and may provide a target that can be manipulated to increase ischemic tolerance of the brain in vivo. Expand
Altered expression and modulation of activity-regulated cytoskeletal associated protein (Arc) in serotonin transporter knockout rats
TLDR
An acute swim stress significantly up-regulated the levels of Arc mRNA in hippocampus and prefrontal cortex, as well as of Zif-268 in frontal cortex, only in SERT(+/-) and SERT(-/-) rats, which may contribute to the neuroplastic and morphological changes observed in depression. Expand
COUP-TFI controls activity-dependent tyrosine hydroxylase expression in adult dopaminergic olfactory bulb interneurons
TLDR
A previously unknown role for COUP-TFI in the adult brain as a key regulator in the control of sensory-dependent plasticity in olfactory dopaminergic neurons is revealed. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 230 REFERENCES
Induction of c-fos and zif/268 gene expression in rat striatal neurons, following stimulation of D1-like dopamine receptors, involves protein kinase A and protein kinase C
TLDR
The results suggest that SKF38393 acts on striatal neurons to stimulate c-fos expression predominantly throughprotein kinase C, but also partially through protein kinase A, which is consistent with the presence of both D1-like receptors on the same neuronal population. Expand
Regulated transcription of the immediate‐early gene Zif268: Mechanisms and gene dosage‐dependent function in synaptic plasticity and memory formation
TLDR
Although the early phase of dentate gyrus LTP is normal in these mice, the later phases are not present, and the ability of the mice to maintain learned information over a 24‐h period is deficient, which shows that spatial learning is particularly sensitive to reduced levels of Zif268. Expand
How necessary is the activation of the immediate early gene zif268 in synaptic plasticity and learning?
TLDR
It is emphasised that understanding the signalling pathways that lead to activation of the IEGs and the downstream targets of these genes will advance the understanding of how functional activation of zif268 may be implicated in processing long-term memories. Expand
Sensory regulation of immediate–early gene expression in mammalian visual cortex: implications for functional mapping and neural plasticity
TLDR
Examination of the expression patterns of AP-1 and Zif268 transcription factors in the mammalian visual cortex under different conditions offers further insight into their likely functions and the extent to which transcription factors may represent patterns of neural activity as a possible prelude to plastic events. Expand
Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1.
TLDR
It is reported that the zif268/egr-1 protein bound in vitro to two sites in the proximal regulatory region of the human synapsin I gene, which concludes that the synapsIn I gene is a target of the zIF268 transcription factor; however, intermediate factors may also be involved in the activation. Expand
Experience-Dependent Plasticity of Mouse Visual Cortex in the Absence of the Neuronal Activity-Dependent Markeregr1/zif268
TLDR
Egr1 is a useful marker of sensory input in mice but is not intrinsically necessary for the experience-dependent plasticity of the visual cortex, underscore a mechanistic distinction between sensory plasticity and long-lasting forms of synaptic potentiation in the hippocampus. Expand
Correlation between the induction of an immediate early gene,zif/268, and long-term potentiation in the dentate gyrus
TLDR
The hypothesis that the immediate early gene zif/268 plays a role as a third messenger in the cascade of cellular and nuclear events that govern the persistence of LTP is supported. Expand
Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation
TLDR
It is found that high-frequency stimulation of the perforant path-granule cell (pp-gc) synapse markedly increases zif/268 messenger RNA levels in the ipsilateral granule cell neurons; mRNA of c-fos, c-jun and jun-B is less consistently increased. Expand
A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories
TLDR
It is shown that whereas mutant mice exhibit early LTP in the dentate gyrus, late LTP is absent when measured 24 and 48 hours after tetanus in the freely moving animal, and Zif268 is essential for the transition from short-to-long-term synaptic plasticity and for the expression of long-term memories. Expand
Activation of immediate early genes and memory formation
TLDR
This review will summarize studies on the expression of transcription factor-encoding immediate early genes in the vertebrate brain during behavioral training and special emphasis will be given to correlative or interventive experimental evidence indicative of a physiological significance of inducible transcription factors for processes underlying learning and memory formation. Expand
...
1
2
3
4
5
...