A gene for neuronal plasticity in the mammalian brain: Zif268/Egr-1/NGFI-A/Krox-24/TIS8/ZENK?

  title={A gene for neuronal plasticity in the mammalian brain: Zif268/Egr-1/NGFI-A/Krox-24/TIS8/ZENK?},
  author={Ewelina Knapska and Leszek Kaczmarek},
  journal={Progress in Neurobiology},

c-Fos and Zif268 in Learning and Memory—Studies on Expression and Function

Since c-Fos and Zif268 are both TF, they bind with specific DNA sequences to regulate the activity of target genes and thus may be the key players in guiding the cell’s response to various stimuli.

Zif268/Egr1 gain of function facilitates hippocampal synaptic plasticity and long-term spatial recognition memory

  • Z. PenkeE. Morice S. Laroche
  • Biology, Psychology
    Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2014
It is found that Zif268 overexpression during the establishment of memory for objects did not change the ability to form a long-term memory of objects, but enhanced the capacity to formA long- term memory of the spatial location of objects.

The transcription factor Zif268/Egr1, brain plasticity, and memory.

Contribution of Egr1/zif268 to Activity-Dependent Arc/Arg3.1 Transcription in the Dentate Gyrus and Area CA1 of the Hippocampus

Findings suggest that hippocampal neural ensembles are normally activated immediately following spatial exploration in Egr1 knockout mice, indicating normal hippocampal encoding of information and provide evidence that in condition of strong activation Egr 1 alone can control late-phases of activity-dependent Arc transcription in the dentate gyrus and area CA1 of the hippocampus.

Transcriptional Signatures of Cellular Plasticity in Mice Lacking the α1 Subunit of GABAA Receptors

The results suggest that the loss of α1-mediated fast inhibition produces diverse transcriptional responses that act to regulate neuronal excitability of individual neurons and stabilize neuronal networks, which may account for the lack of severe abnormalities in α1 null mutants.

Altered expression and modulation of activity-regulated cytoskeletal associated protein (Arc) in serotonin transporter knockout rats

COUP-TFI controls activity-dependent tyrosine hydroxylase expression in adult dopaminergic olfactory bulb interneurons

A previously unknown role for COUP-TFI in the adult brain as a key regulator in the control of sensory-dependent plasticity in olfactory dopaminergic neurons is revealed.

Dopamine D2 receptor activation leads to an up‐regulation of glial cell line–derived neurotrophic factor via Gβγ‐Erk1/2‐dependent induction of Zif268

Results suggest that D2R activation induces a Gβγ‐ and extracellular signal–regulated kinase 1/2‐dependent increase in the level of Zif268, which functions to directly up‐regulate the expression of GDNF.



Regulated transcription of the immediate‐early gene Zif268: Mechanisms and gene dosage‐dependent function in synaptic plasticity and memory formation

Although the early phase of dentate gyrus LTP is normal in these mice, the later phases are not present, and the ability of the mice to maintain learned information over a 24‐h period is deficient, which shows that spatial learning is particularly sensitive to reduced levels of Zif268.

Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1.

It is reported that the zif268/egr-1 protein bound in vitro to two sites in the proximal regulatory region of the human synapsin I gene, which concludes that the synapsIn I gene is a target of the zIF268 transcription factor; however, intermediate factors may also be involved in the activation.

Experience-Dependent Plasticity of Mouse Visual Cortex in the Absence of the Neuronal Activity-Dependent Markeregr1/zif268

Egr1 is a useful marker of sensory input in mice but is not intrinsically necessary for the experience-dependent plasticity of the visual cortex, underscore a mechanistic distinction between sensory plasticity and long-lasting forms of synaptic potentiation in the hippocampus.

Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation

It is found that high-frequency stimulation of the perforant path-granule cell (pp-gc) synapse markedly increases zif/268 messenger RNA levels in the ipsilateral granule cell neurons; mRNA of c-fos, c-jun and jun-B is less consistently increased.

A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories

It is shown that whereas mutant mice exhibit early LTP in the dentate gyrus, late LTP is absent when measured 24 and 48 hours after tetanus in the freely moving animal, and Zif268 is essential for the transition from short-to-long-term synaptic plasticity and for the expression of long-term memories.

Activation of immediate early genes and memory formation

This review will summarize studies on the expression of transcription factor-encoding immediate early genes in the vertebrate brain during behavioral training and special emphasis will be given to correlative or interventive experimental evidence indicative of a physiological significance of inducible transcription factors for processes underlying learning and memory formation.

The Zinc Finger Transcription Factor Zif268/Egr-1 Is Essential for Schwann Cell Expression of the p75 NGF Receptor

Nerve injury alters the function of Schwann cells from quiescent, myelin forming cells to proliferating cells that facilitate nerve repair. The transcription factor, Zif268, may be involved in