A gene expression signature that can predict the recurrence of tamoxifen-treated primary breast cancer.

@article{Chanrion2008AGE,
  title={A gene expression signature that can predict the recurrence of tamoxifen-treated primary breast cancer.},
  author={Ma{\"i}a Chanrion and Vincent N{\`e}gre and H{\'e}l{\`e}ne Fontaine and Nicolas Salvetat and Fr{\'e}d{\'e}ric Bibeau and Ga{\"e}tan Mac Grogan and Louis Mauriac and Dionyssios Katsaros and F. Molina and Charles Theillet and Jean-Marie Darbon},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 6},
  pages={1744-52}
}
PURPOSE The identification of a molecular signature predicting the relapse of tamoxifen-treated primary breast cancers should help the therapeutic management of estrogen receptor-positive cancers. EXPERIMENTAL DESIGN A series of 132 primary tumors from patients who received adjuvant tamoxifen were analyzed for expression profiles at the whole-genome level by 70-mer oligonucleotide microarrays. A supervised analysis was done to identify an expression signature. RESULTS We defined a 36-gene… CONTINUE READING
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