A gene expression signature that can predict the recurrence of tamoxifen-treated primary breast cancer.

  title={A gene expression signature that can predict the recurrence of tamoxifen-treated primary breast cancer.},
  author={Ma{\"i}a Chanrion and Vincent N{\`e}gre and H{\'e}l{\`e}ne Fontaine and Nicolas Salvetat and Fr{\'e}d{\'e}ric Bibeau and Ga{\"e}tan Mac Grogan and Louis Mauriac and Dionyssios Katsaros and F. Molina and Charles Theillet and Jean-Marie Darbon},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={14 6},
PURPOSE The identification of a molecular signature predicting the relapse of tamoxifen-treated primary breast cancers should help the therapeutic management of estrogen receptor-positive cancers. EXPERIMENTAL DESIGN A series of 132 primary tumors from patients who received adjuvant tamoxifen were analyzed for expression profiles at the whole-genome level by 70-mer oligonucleotide microarrays. A supervised analysis was done to identify an expression signature. RESULTS We defined a 36-gene… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures and tables from this paper.


Publications citing this paper.
Showing 1-10 of 74 extracted citations

A Systems Biology Approach to Identify Affected Regulatory and Signaling Circuits in Protein Interaction Networks

2009 International Joint Conference on Bioinformatics, Systems Biology and Intelligent Computing • 2009
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-4 of 4 references

The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2006

Gene expression profiling predicts clinical outcome of breast cancer

LJ, H Dai, MJ van de Vijver
Lancet • 2002

Similar Papers

Loading similar papers…