A gene expression signature shared by human mature oocytes and embryonic stem cells

@article{Assou2008AGE,
  title={A gene expression signature shared by human mature oocytes and embryonic stem cells},
  author={Said Assou and Doris Cerecedo and Sylvie Tondeur and V{\'e}ronique Pantesco and Outi Hovatta and Bernard Klein and Samir Hamamah and John De Vos},
  journal={BMC Genomics},
  year={2008},
  volume={10},
  pages={10 - 10}
}
The first week of human pre-embryo development is characterized by the induction of totipotency and then pluripotency. The understanding of this delicate process will have far reaching implication for in vitro fertilization and regenerative medicine. Human mature MII oocytes and embryonic stem (ES) cells are both able to achieve the feat of cell reprogramming towards pluripotency, either by somatic cell nuclear transfer or by cell fusion, respectively. Comparison of the transcriptome of these… CONTINUE READING
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