A gene expression signature classifying telomerase and ALT immortalisation reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT

@inproceedings{LaffertyWhyte2009AGE,
  title={A gene expression signature classifying telomerase and ALT immortalisation reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT},
  author={Kyle Lafferty-Whyte and Claire J. Cairney and Malcolm B. Will and Nedime Serakinci and Maria-Grazia Daidone and Nadia Zaffaroni and Alan E. Bilsland and W. Nicol Keith},
  booktitle={Oncogene},
  year={2009}
}
Telomere length is maintained by two known mechanisms, the activation of telomerase or alternative lengthening of telomeres (ALT). The molecular mechanisms regulating the ALT phenotype are poorly understood and it is unknown how the decision of which pathway to activate is made at the cellular level. We have shown earlier that active repression of telomerase gene expression by chromatin remodelling of the promoters is one mechanism of regulation; however, other genes and signalling networks are… CONTINUE READING
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