A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival.

@article{Singh2009AGE,
  title={A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival.},
  author={Anurag Singh and Patricia Greninger and Daniel Rhodes and Louise A. Koopman and Sheila M Violette and Nabeel Bardeesy and Jeffrey Settleman},
  journal={Cancer cell},
  year={2009},
  volume={15 6},
  pages={489-500}
}
K-ras mutations occur frequently in epithelial cancers. Using short hairpin RNAs to deplete K-Ras in lung and pancreatic cancer cell lines harboring K-ras mutations, two classes were identified-lines that do or do not require K-Ras to maintain viability. Comparing these two classes of cancer cells revealed a gene expression signature in K-Ras-dependent cells, associated with a well-differentiated epithelial phenotype, which was also seen in primary tumors. Several of these genes encode… CONTINUE READING
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