A gene expression map of human chromosome 21 orthologues in the mouse

@article{initiative2002AGE,
  title={A gene expression map of human chromosome 21 orthologues in the mouse},
  author={The HSA21 expression map initiative},
  journal={Nature},
  year={2002},
  volume={420},
  pages={586-590}
}

• The HSA21 expression map initiative
• Published 2002
• DOI:10.1038/nature01270

The DNA sequence of human chromosome 21 (HSA21)1 has opened the route for a systematic molecular characterization of all of its genes. Trisomy 21 is associated with Down's syndrome, the most common genetic cause of mental retardation in humans. The phenotype includes various organ dysmorphies, stereotypic craniofacial anomalies and brain malformations2. Molecular analysis of congenital aneuploidies poses a particular challenge because the aneuploid region contains many protein-coding genes… CONTINUE READING

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