A gene-expression-based neural code for food abundance that modulates lifespan

@inproceedings{Entchev2015AGN,
  title={A gene-expression-based neural code for food abundance that modulates lifespan},
  author={Eugeni V. Entchev and Dhaval S. Patel and Mei Zhan and Andrew J Steele and Hang Lu and QueeLim Ch'ng},
  booktitle={eLife},
  year={2015}
}
How the nervous system internally represents environmental food availability is poorly understood. Here, we show that quantitative information about food abundance is encoded by combinatorial neuron-specific gene-expression of conserved TGFβ and serotonin pathway components in Caenorhabditis elegans. Crosstalk and auto-regulation between these pathways alters the shape, dynamic range, and population variance of the gene-expression responses of daf-7 (TGFβ) and tph-1 (tryptophan hydroxylase) to… CONTINUE READING
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