A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast.

@article{Andersen2007AGD,
  title={A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast.},
  author={Gorm Andersen and Birgit Andersen and Doreen Dobritzsch and Klaus D Schnackerz and Jure Pi{\vs}kur},
  journal={The FEBS journal},
  year={2007},
  volume={274 7},
  pages={1804-17}
}
In humans, beta-alanine (BAL) and the neurotransmitter gamma-aminobutyrate (GABA) are transaminated by a single aminotransferase enzyme. Apparently, yeast originally also had a single enzyme, but the corresponding gene was duplicated in the Saccharomyces kluyveri lineage. SkUGA1 encodes a homologue of Saccharomyces cerevisiae GABA aminotransferase, and SkPYD4 encodes an enzyme involved in both BAL and GABA transamination. SkPYD4 and SkUGA1 as well as S. cerevisiae UGA1 and Schizosaccharomyces… CONTINUE READING