A gene atlas of ‘structural immunity’

  title={A gene atlas of ‘structural immunity’},
  author={Kirsty Minton},
  journal={Nature Reviews Immunology},
  pages={518 - 519}
  • Kirsty Minton
  • Published 13 July 2020
  • Biology
  • Nature Reviews Immunology
Multi-omics profiling of endothelial cells, epithelial cells and fibroblasts from 12 mouse organs was used to create an atlas of immune gene activity in structural cells. 


Structural cells are key regulators of organ-specific immune response

This study highlights the prevalence and organ-specific complexity of immune gene activity in non-haematopoietic structural cells, and it provides a high-resolution, multi-omics atlas of the epigenetic and transcriptional networks that regulate structural cells in the mouse.