A gene-alteration profile of human lung cancer cell lines.

  title={A gene-alteration profile of human lung cancer cell lines.},
  author={Raquel Blanco and Reika Iwakawa and Moying Tang and Takashi Kohno and B{\'a}rbara Angulo and Rub{\'e}n P{\'i}o and Luis M. Montuenga and John D. Minna and Jun Yokota and M Sanchez-Cespedes},
  journal={Human mutation},
  volume={30 8},
Aberrant proteins encoded from genes altered in tumors drive cancer development and may also be therapeutic targets. Here we derived a comprehensive gene-alteration profile of lung cancer cell lines. We tested 17 genes in a panel of 88 lung cancer cell lines and found the rates of alteration to be higher than previously thought. Nearly all cells feature inactivation at TP53 and CDKN2A or RB1, whereas BRAF, MET, ERBB2, and NRAS alterations were infrequent. A preferential accumulation of… CONTINUE READING
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