A gas chromatographic mass spectrometric assay for the determination of aphidicolin in plasma of cancer patients.

@article{Rotondo1989AGC,
  title={A gas chromatographic mass spectrometric assay for the determination of aphidicolin in plasma of cancer patients.},
  author={Serenella Rotondo and Massimo Zucchetti and Christiana Sessa and Maurizio D'Incalci and Emilio Benfenati and Roberto Fanelli},
  journal={Journal of pharmaceutical sciences},
  year={1989},
  volume={78 5},
  pages={399-401}
}
A gas chromatographic-mass spectrometric (GC-MS) method is described for the determination of the novel anticancer agent aphidicolin in plasma. The extraction was carried out in a solvent mixture of hexane:isopropanol (10:1) and the external standard aphidicolane was added after evaporation of the organic phase. The residue was then redissolved in a… CONTINUE READING