A gammaherpesvirus G protein-coupled receptor homologue is required for increased viral replication in response to chemokines and efficient reactivation from latency.

@article{Lee2003AGG,
  title={A gammaherpesvirus G protein-coupled receptor homologue is required for increased viral replication in response to chemokines and efficient reactivation from latency.},
  author={Bong Joo Lee and Ulrich Koszinowski and Sally R. Sarawar and Heiko Adler},
  journal={Journal of immunology},
  year={2003},
  volume={170 1},
  pages={
          243-51
        }
}
The open reading frame (ORF) 74 of gamma-2-herpesviruses encodes a G protein-coupled receptor which is highly conserved in members of this subfamily and is homologous to the CXCR2 chemokine receptor. The viral G protein-coupled receptor has been implicated in viral pathogenesis. However, the advantage of such chemokine receptor homologues to the virus is currently unknown. To address this, we constructed ORF74 deletion mutants of a mouse gamma-2-herpesvirus (MHV-68) and examined the effect of… CONTINUE READING
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