A gamma delta T cell specific surface receptor (WC1) signaling G0/G1 cell cycle arrest.

@article{Takamatsu1997AGD,
  title={A gamma delta T cell specific surface receptor (WC1) signaling G0/G1 cell cycle arrest.},
  author={Haru-H. Takamatsu and Paul A. Kirkham and Robert Michael Evans Parkhouse},
  journal={European journal of immunology},
  year={1997},
  volume={27 1},
  pages={105-10}
}
Three monoclonal antibodies (mAb; SC-6, SC-12, and SC-29) reactive with the gammadelta T cell-restricted antigen WC1 were obtained immunizing mice with an ovine interleukin (IL)-2-dependent gammadelta T cell line. These mAb strongly inhibited DNA synthesis in IL-2-dependent gammadelta T cell lines with cell cycle arrest in G0/G1 phase, but did not induce apoptosis. The mAb-induced growth arrest was reversible, either by removing the mAb or by co-culture with mitogen or anti-CD3 in the presence… CONTINUE READING