A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53-null mammary epithelial cell model.

@article{Murphy2000AGO,
  title={A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53-null mammary epithelial cell model.},
  author={Kristen L. Murphy and Andrew P Dennis and Jeffrey M. Rosen},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2000},
  volume={14 14},
  pages={2291-302}
}
Approximately 40% of human breast cancers contain alterations in the tumor suppressor p53. The p53 172R-H gain-of-function mutant (equivalent to the common 175R-H human breast cancer mutant) has been shown to promote aneuploidy and tumorigenesis in the mammary gland in transgenic mice and may affect genomic stability in part by causing centrosome abnormalities. The precise mechanism of action of these gain-of-function mutants is not well understood, and has been studied primarily in fibroblast… CONTINUE READING