A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial Inappropriate Sinus Tachycardia.

Abstract

Department of Biosciences, The PaceLab and ‘Centro Interuniversitario di Medicina Molecolare e Biofisica Applicata’, Università degli Studi di Milano, via Celoria 26, 20133 Milano, Italy; Department of Cardiology, San Leopoldo Mandic Hospital, Merate, Italy; Cardiovascular Department, ‘Ospedali Riuniti di Trieste’, University Hospital, Trieste, Italy; II Medical Department, Cardiology, Klinikum Coburg, Coburg, Germany; IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy; and Humanitas Gavazzeni Clinics, Bergamo, Italy

DOI: 10.1093/eurheartj/ehv582

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Cite this paper

@article{Baruscotti2017AGM, title={A gain-of-function mutation in the cardiac pacemaker HCN4 channel increasing cAMP sensitivity is associated with familial Inappropriate Sinus Tachycardia.}, author={Mirko Baruscotti and Annalisa Bucchi and Raffaella Milanesi and Manuel Paina and Andrea Barbuti and Tomaso Gnecchi-Ruscone and Elisabetta Bianco and Laura Vitali-Serdoz and Riccardo Cappato and Dario DiFrancesco}, journal={European heart journal}, year={2017}, volume={38 4}, pages={280-288} }