A fusion DNA vaccine that targets antigen-presenting cells increases protection from viral challenge.

@article{Deliyannis2000AFD,
  title={A fusion DNA vaccine that targets antigen-presenting cells increases protection from viral challenge.},
  author={Georgia Deliyannis and James S. Boyle and Jamie L. Brady and Lorena Elizabeth Brown and Andrew M. Lew},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 12},
  pages={
          6676-80
        }
}
Improving the immunological potency, particularly the Ab response, is a serious hurdle for the protective efficacy and hence broad application of DNA vaccines. We examined the immunogenicity and protective efficacy of a hemagglutinin-based influenza DNA vaccine that was targeted to antigen-presenting cells (APCs) by fusion to CTLA4. The targeted vaccine was shown to induce an accelerated and increased Ab response (as compared with those receiving the nontargeted control) that was predominated… CONTINUE READING
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