A further update on the role of excitotoxicity in the pathogenesis of Parkinson’s disease

@article{Ambrosi2013AFU,
  title={A further update on the role of excitotoxicity in the pathogenesis of Parkinson’s disease},
  author={Giulia Ambrosi and Silvia Cerri and Fabio Blandini},
  journal={Journal of Neural Transmission},
  year={2013},
  volume={121},
  pages={849-859}
}
Increased levels of extracellular glutamate and hyperactivation of glutamatergic receptors in the basal ganglia trigger a critical cascade of events involving both intracellular pathways and cell-to-cell interactions that affect cell viability and promote neuronal death. The ensemble of these glutamate-triggered events is responsible for excitotoxicity, a phenomenon involved in several pathological conditions affecting the central nervous system, including a neurodegenerative disease such as… CONTINUE READING
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