A further study of the vasodilator and negative inotropic mechanisms of action of nicorandil and its congeners in the canine heart

@article{Satoh2004AFS,
  title={A further study of the vasodilator and negative inotropic mechanisms of action of nicorandil and its congeners in the canine heart},
  author={K. Satoh and K. Orito and F. Yoneyama and N. Taira},
  journal={Cardiovascular Drugs and Therapy},
  year={2004},
  volume={8},
  pages={227-234}
}
SummaryThe vasodilator and negative inotropic mechanisms of action of nicorandil and its congeners (SG-209, SG-103, and SG-86) were investigated in isolated canine papillary muscle preparations cross-circulated through the anterior septal artery with support dogs. SG-209, SG-103, and SG-86 were obtained by replacement of the nitroxyl group of nicorandil by acetoxyl, nicotinoyloxyl, and hydroxyl groups, respectively. Nicorandil (0.03–10 µmol), SG-209 (0.1–10 µmol), SG-103 (1–30 µmol), and SG-86… Expand
Pharmacokinetics of nicorandil in dogs with mild mitral regurgitation.

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