A further case with a small supernumerary marker chromosome (sSMC) derived from chromosome 1--evidence for high variability in mosaicism in different tissues of sSMC carriers.

@article{Fickelscher2007AFC,
  title={A further case with a small supernumerary marker chromosome (sSMC) derived from chromosome 1--evidence for high variability in mosaicism in different tissues of sSMC carriers.},
  author={Ina Fickelscher and Heike Starke and E. R. Schulze and G{\"u}nther Ernst and Nadezda Kosyakova and Hasmik Mkrtchyan and Kay MacDermont and Neil J Sebire and Thomas Liehr},
  journal={Prenatal diagnosis},
  year={2007},
  volume={27 8},
  pages={
          783-5
        }
}
  • Ina Fickelscher, Heike Starke, +6 authors Thomas Liehr
  • Published in Prenatal diagnosis 2007
  • Biology, Medicine
  • A prenatally ascertained case with a de novo small supernumerary marker chromosome (sSMC) derived from chromosome 1 is reported. Due to a fetal heart defect the parents decided in favour of an induced abortion. Postmortem, a molecular cytogenetic study on eleven formalin fixed, paraffin-embedded tissues of the fetus was performed, to further characterize the levels of mosaicism of the sSMC(1). sSMC presence varied between 13 and 62% within different tissues of sSMC carriers. This finding is… CONTINUE READING

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