A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase.

@article{Bennett2000AFC,
  title={A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase.},
  author={Bryson D. Bennett and Paul E. Denis and Mitsuru Haniu and David B Teplow and Steve M. Kahn and J. C. Louis and Martin Citron and Robert Vassar},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 48},
  pages={37712-7}
}
The novel transmembrane aspartic protease BACE (for Beta-site APP Cleaving Enzyme) is the beta-secretase that cleaves amyloid precursor protein to initiate beta-amyloid formation. As such, BACE is a prime therapeutic target for the treatment of Alzheimer's disease. BACE, like other aspartic proteases, has a propeptide domain that is removed to form the mature enzyme. BACE propeptide cleavage occurs at the sequence RLPR downward arrowE, a potential furin recognition motif. Here, we explore the… CONTINUE READING

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