A fungal pH-responsive signaling pathway regulating Aspergillus adaptation and invasion into the cornea.

@article{Hua2010AFP,
  title={A fungal pH-responsive signaling pathway regulating Aspergillus adaptation and invasion into the cornea.},
  author={Xia Hua and Xiaoyong Yuan and Kirk R. Wilhelmus},
  journal={Investigative ophthalmology & visual science},
  year={2010},
  volume={51 3},
  pages={1517-23}
}
PURPOSE To investigate the role of PalB and PacC, two components of a pH-responsive signal-transduction pathway of Aspergillus nidulans, during the pathogenesis of fungal infection of the cornea. METHODS Fungal strains included an A. nidulans wild-type isolate (A83), loss-of-function A. nidulans mutants of the palB (B7) or pacC (C6309) genes, and reconstituted genotypic strains (B7R and C6309R). Doubling times and radial growth rates were examined under neutral and acidic conditions. Corneal… CONTINUE READING