A fungal nonribosomal peptide synthetase module that can synthesize thiopyrazines.

@article{Qiao2011AFN,
  title={A fungal nonribosomal peptide synthetase module that can synthesize thiopyrazines.},
  author={Kangjian Qiao and Hui Zhou and Wei Xu and Wenjun Zhang and Neil Garg and Yi Tang},
  journal={Organic letters},
  year={2011},
  volume={13 7},
  pages={1758-61}
}
A nonribosomal peptide synthetase-like enzyme (NRPS325) from Aspergillus terreus was reconstituted in vitro and was shown to synthesize thiopyrazines using an unprecedented mechanism. Substrate promiscuity of NRPS325 toward different amino acids and free thiols was explored to produce >60 different thiopyrazine compounds. 

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