A fundamental transcription factor for bone and cartilage.


Cbfa1-deficient mice were found to show a complete lack of bone formation owing to the maturational arrest of osteoblasts. Cbfa1 plays key roles in the determination of osteoblastic lineage from multipotential mesenchymal cells, their differentiation into mature osteoblasts, and transcriptional regulation of bone matrix-related genes. Cbfa1 positively… (More)


Cite this paper

@article{Komori2000AFT, title={A fundamental transcription factor for bone and cartilage.}, author={Toshihisa Komori}, journal={Biochemical and biophysical research communications}, year={2000}, volume={276 3}, pages={813-6} }